Let's save ourselves

Ourselves

Irradiating Ourselves

Background: Efficient incorporation of the cellular cytidine deaminase APOBEC3G (APO3G) into HIV-1 virions is necessary for its antiviral activity. Even though cellular RNAs are known to be nonspecifically incorporated into virus particles, we have previously found that encapsidation of APO3G into HIV-1 virions is specifically enhanced by viral genomic RNA. Intracellularly, APO3G was found to f...

Constructability of Trip-lets

A trip-let is an object as shown on the cover of Hofstadter’s book Gödel, Escher, Bach: a solid, threedimensional object that, when viewed from three orthogonal directions, shows three different letters. In this paper we consider two problems related to the construction of such objects for a given set of three letters. First, we want to know whether the silhouettes of the object correspond to t...

On Desugaring Polymorphic Lets

Existing type literature has conflicting views on desugaring polymorphic lets to lambda terms. The conflict arises because, in certain cases, desugaring does not preserve typing. We describe a transformation of polymorphic lets to monomorphic lets such that, when the monomorphic lets are desugared, the typing is preserved. Our transformation requires no changes to either term or type syntax. Th...

FANCJ lets chromatin stay true

10.1083/jcb.2011iti1jcb.2011iti1Mitch [email protected] g1.epsIn This IssueNewsFANCJ lets chromatin stay true S chwab et al. show how a protein that unkinks DNA might help cells to maintain chromatin organization during DNA replication. The DNA replication machinery can run into ...